PeRiOperative VItamin C to Reduce perSistent paIn After tOtal kNee Arthroplasty (PROVISION): a Pilot Multicentre Randomized Controlled Trial
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients \>18 years old
• Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee
Locations
Other Locations
Canada
Mount Sinai Hospital
RECRUITING
Toronto
Sunnybrook - Holland Centre
RECRUITING
Toronto
Toronto Western Hospital
RECRUITING
Toronto
Contact Information
Primary
James Khan, MD
James.Khan@medportal.ca
416-340-4800
Backup
Nour Ayach
Nour.Ayach@uhn.ca
(416) 340 4800
Time Frame
Start Date: 2024-04-16
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 300
Treatments
Experimental: Intervention
Preoperative Vitamin C capsules
Placebo_comparator: Placebo
Preoperative placebo capsules
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR), The Arthritis Society, Canada
Leads: University Health Network, Toronto